Tan C E, Moscoso G J
Department of Pediatric Surgery, Singapore General Hospital.
Pathol Int. 1994 Aug;44(8):587-99. doi: 10.1111/j.1440-1827.1994.tb01719.x.
The developing biliary system in normal human embryos from 29 days to 8 weeks post-fertilization was studied. The primitive extrahepatic bile duct that originates from the embryonic hepatic foregut diverticulum is in contact with the hepatic anlage from the start of organogenesis and remains so throughout the gestational ages examined. The primitive extrahepatic bile duct maintains continuity with the ductal plate from which intrahepatic bile ducts are eventually formed. Contrary to long-held concepts of biliary development, no 'solid stage' of entodermal occlusion of the common bile duct lumen was found at any stage of gestation in the material investigated. Therefore, biliary atresia is not caused by incomplete vacuolization of the 'solid stage'.
对受精后29天至8周的正常人类胚胎中发育中的胆道系统进行了研究。起源于胚胎肝前肠憩室的原始肝外胆管从器官发生开始就与肝原基接触，并且在所研究的整个孕周内一直如此。原始肝外胆管与最终形成肝内胆管的胆管板保持连续性。与长期以来关于胆道发育的概念相反，在所研究的材料中，在妊娠的任何阶段都未发现胆总管腔的内胚层闭塞的“实性阶段”。因此，胆道闭锁不是由“实性阶段”的不完全空泡化引起的。
