Dalla Barba G, Boller F
Institut National de la Santé et de la Recherche Médicale, Paris, France.
Curr Opin Neurol. 1994 Aug;7(4):305-9. doi: 10.1097/00019052-199408000-00005.
The explosion of research aimed at exploring degenerative dementias in the past 20 years has produced a great deal of knowledge concerning not only Alzheimer's disease but also other conditions referred to as non-Alzheimer degenerative diseases. The conditions reviewed here fall broadly into two main categories: diseases with focal (lobar) atrophy and diffuse Lewy body disease. These conditions, which are described more and more often in centers around the world, represent entities different from Alzheimer's disease not only from a clinical and pathological viewpoint, but also in terms of genetics and perhaps even in terms of therapeutic responses. In view of the numerous therapeutic trials currently underway, the distinction between Alzheimer's disease and non-Alzheimer degenerative diseases has acquired new importance.
在过去20年里，旨在探索退行性痴呆症的研究激增，不仅产生了大量关于阿尔茨海默病的知识，还带来了关于其他被称为非阿尔茨海默退行性疾病的知识。这里所综述的疾病大致可分为两大类：局灶性（叶性）萎缩性疾病和弥漫性路易体病。这些疾病在世界各地的医疗中心被越来越频繁地描述，它们不仅在临床和病理学观点上，而且在遗传学方面，甚至可能在治疗反应方面，都代表着与阿尔茨海默病不同的实体。鉴于目前正在进行众多治疗试验，阿尔茨海默病与非阿尔茨海默退行性疾病之间的区别已具有新的重要性。
