L-2-氨基-4-膦酰丁酸（L-AP4）和反式-2-氨基环戊烷-1,3-二羧酸（ACPD）对两栖动物视网膜内源性多巴胺释放的抑制作用。
Inhibition of endogenous dopamine release in amphibian retina by L-2-amino-4-phosphonobutyric acid (L-AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD).
作者信息
Boatright J H, Gordon J R, Iuvone P M
机构信息
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090.
出版信息
Brain Res. 1994 Jun 27;649(1-2):339-42. doi: 10.1016/0006-8993(94)91084-7.
The metabotropic glutamate receptor agonists 2-amino-4-phosphonobutyric acid (AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD) blocked light-stimulated dopamine release from Xenopus laevis retina. ACPD suppressed release in darkness but AP4 did not. AP4 blocked release stimulated in darkness by picrotoxin, a GABA-A receptor antagonist. The data suggest that regulation of dopamine release in Xenopus retina involves subpopulations of metabotropic glutamate receptors.
代谢型谷氨酸受体激动剂2-氨基-4-膦酰丁酸（AP4）和反式-2-氨基环戊烷-1,3-二羧酸（ACPD）可阻断非洲爪蟾视网膜受光刺激后的多巴胺释放。ACPD在黑暗中可抑制释放，但AP4无此作用。AP4可阻断由γ-氨基丁酸A受体拮抗剂荷包牡丹碱在黑暗中刺激引起的释放。这些数据表明，非洲爪蟾视网膜中多巴胺释放的调节涉及代谢型谷氨酸受体亚群。
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