Xia T L, Deng F M, Feng T
Institute of Urology, Beijing Medical University.
Zhonghua Yi Xue Za Zhi. 1994 May;74(5):306-8, 327.
67 patients with serum prostate specific antigen (PSA) over 4ng/ml were investigated pathologically. All the patients had prostatic lesions: prostate cancer (24) and benign prostatic lesions (43). The serum PSA was conspicuously higher in the carcinoma group than in the benign group (P < 0.01). When 10ng/ml was used as the low limit to detect prostate cancer, the sensitivity and specificity were 83.3% and 74.4% respectively. We suggest that the range of serum PSA from 4.0 to 10.0ng/ml should be considered dangerous in detecting prostate cancer. The epithelium-blood barrier lesion and epithelial hyperplasia of the prostate might be the pathological basis for the elevation of serum PSA.
对67例血清前列腺特异性抗原（PSA）超过4ng/ml的患者进行了病理检查。所有患者均有前列腺病变：前列腺癌（24例）和良性前列腺病变（43例）。癌组血清PSA明显高于良性组（P<0.01）。以10ng/ml作为检测前列腺癌的下限，其敏感性和特异性分别为83.3%和74.4%。我们认为，在检测前列腺癌时，血清PSA在4.0至10.0ng/ml范围内应被视为危险范围。前列腺上皮-血屏障损伤和上皮增生可能是血清PSA升高的病理基础。
