Yang C, Shen D, Yang X
Institute of Hematology, CAMS and PUMC, Tianjin.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1994 Feb;16(1):39-42.
Two monoclonal antibodies (McAbs), HI160 and HI166, recognize different epitopes of the CD71 antigen. Their biological properties have been studied, and the results demonstrated that both had down-regulation effects. HI160 McAb not only inhibited the activation and proliferation of T and B lymphocytes but also the growth of CFU-GM. HI166 McAb only inhibited the activation and proliferation of T lymphocytes. The differences in the biological properties of the two CD71 McAbs might be due to the different epitopes recognized by them. The application value of these McAbs is discussed.
两种单克隆抗体（McAbs），HI160和HI166，识别CD71抗原的不同表位。已经对它们的生物学特性进行了研究，结果表明两者都具有下调作用。HI160单克隆抗体不仅抑制T和B淋巴细胞的活化和增殖，还抑制CFU-GM的生长。HI166单克隆抗体仅抑制T淋巴细胞的活化和增殖。两种CD71单克隆抗体生物学特性的差异可能是由于它们识别的表位不同。讨论了这些单克隆抗体的应用价值。
