Obermair A, Czerwenka K, Kurz C, Kaider A, Sevelda P
I. Universitäts-Frauenklinik, Universität, Wien.
Dtsch Med Wochenschr. 1994 Nov 4;119(44):1491-6. doi: 10.1055/s-2008-1058863.
Blood vessel invasion was investigated with haematoxylin-eosin (HE) staining and immunohistochemical staining for factor VIII antigen (F VIII) in 106 patients with primary carcinoma of the breast, in order to compare their value in prognosticating the probability of recurrence. Blood vessel invasion was diagnosed in 65 cases (61.9%) by HE, but in only 45 (43.4%) by F VIII staining. Lymph-node status and blood vessel invasion correlated positively on HE (r = 0.73; P = 0.0001), but not so on F VIII staining. Multivariate logistic regression showed blood vessel invasion to be a strongly independent prognostic factor for recurrence-free survival with F VIII staining (odds ratio: = 7.19; P = 0.0001), while HE staining was not independent from other prognostic factors. These preliminary data thus suggest that demonstrating vascular invasion by F VIII staining may identify those patients with a very high risk of recurrence, independent of lymph-node status.
为比较苏木精-伊红（HE）染色和因子VIII抗原（F VIII）免疫组化染色在预测106例原发性乳腺癌患者复发概率方面的价值，对其进行了血管侵犯情况的研究。HE染色诊断出65例（61.9%）存在血管侵犯，而F VIII染色仅诊断出45例（43.4%）。HE染色显示淋巴结状态与血管侵犯呈正相关（r = 0.73；P = 0.0001），但F VIII染色未显示出这种相关性。多因素逻辑回归分析显示，F VIII染色的血管侵犯是无复发生存的一个强独立预后因素（优势比：= 7.19；P = 0.0001），而HE染色并非独立于其他预后因素。因此，这些初步数据表明，通过F VIII染色显示血管侵犯可能识别出那些复发风险非常高的患者，且与淋巴结状态无关。
