Calabrese E J, Leonard D A, Baldwin L A
School of Public Health, University of Massachusetts, Amherst 01003.
Ecotoxicol Environ Saf. 1994 Feb;27(1):105-6. doi: 10.1006/eesa.1994.1010.
A single antimitotic dose of colchicine administered 24 hr after a single ip dose of CCl4 profoundly enhanced lethality in the adult Sprague-Dawley male rat from < 10% to over > or = 70% within the next 24 hr. These findings suggest that disruption of normal hepatic cellular repair processes is a critical factor affecting the outcome of CCl4 intoxication.
