Dyess D L, Powell R W, Swafford A N, Schmacht D C, Roberts W S, Ferrara J J, Ardell J L
Department of Surgery, University of South Alabama College of Medicine, Mobile.
J Pediatr Surg. 1994 Aug;29(8):1097-102. doi: 10.1016/0022-3468(94)90287-9.
Newborn piglets (aged 1 to 2 days and 7 to 14 days) were used to study (1) the redistribution of organ blood flow after a 25% acute blood loss and (2) the response to resuscitation with shed blood (20 mL/kg), crystalloid (normal saline [NS] or lactated Ringer's [LR]; 60 mL/kg), and colloid (Dextran-40, 20 mL/kg). Hemodynamic parameters showed little differences in the response to hemorrhage and resuscitation. The two age groups had no significant differences in parameters or blood flow (results combined). The animals maintained flow to the heart and central nervous system (CNS) and had significantly decreased flow to the kidneys and splanchnic organs. In the gastrointestinal tract, the small intestine was affected most severely, with a significant decrease in blood flow, especially to the mucosa. In all organ systems, Dextran 40 restored blood flow to levels significantly above the baseline. Shed blood and crystalloid restored flow to organs sustaining decreased flow, but crystalloid did not restore flow to the baseline level in the kidney and all segments of the gastrointestinal tract.
新生仔猪（1至2日龄和7至14日龄）被用于研究：（1）急性失血25%后器官血流的重新分布；（2）对自体失血（20 mL/kg）、晶体液（生理盐水[NS]或乳酸林格液[LR]；60 mL/kg）和胶体液（右旋糖酐-40，20 mL/kg）复苏的反应。血流动力学参数显示，在出血和复苏反应方面差异不大。两个年龄组在参数或血流方面无显著差异（结果合并）。动物维持了心脏和中枢神经系统（CNS）的血流，而肾脏和内脏器官的血流显著减少。在胃肠道中，小肠受影响最严重，血流显著减少，尤其是黏膜血流。在所有器官系统中，右旋糖酐40使血流恢复到显著高于基线的水平。自体失血和晶体液使血流减少的器官恢复了血流，但晶体液未能使肾脏和胃肠道各段的血流恢复到基线水平。
