川崎病患者血清可溶性E选择素水平
Serum soluble E-selectin levels in Kawasaki disease.
作者信息
Kim D S, Lee K Y
机构信息
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Scand J Rheumatol. 1994;23(5):283-6. doi: 10.3109/03009749409103730.
Serum sE-selectin levels in KD were tested. In the KD patients' sera during the acute phase, the levels of circulating sE-selectin were markedly elevated (27.5 +/- 10.9 ng/ml) compared to 3.1 +/- 1.0 ng/ml in the control subjects (p < 0.0001). The serum sE-selectin levels remained significantly elevated in the subacute phase (16.2 +/- 7.3 ng/ml; p < 0.005). The acute phase sE-selectin levels and TNF-alpha correlated well in a linear pattern (r2 = 0.64, p < 0.01). Also the acute phase sE-selectin levels and IL-6 were well correlated (r2 = 0.54, p < 0.05). The elevated serum sE-selectin levels in patients with KD provides additional evidence for the relationship between acute vasculitis and serum sE-selectin.
检测了川崎病（KD）患者的血清可溶性E选择素（sE-selectin）水平。在急性期KD患者的血清中，循环sE-selectin水平显著升高（27.5±10.9 ng/ml），而对照组为3.1±1.0 ng/ml（p<0.0001）。在亚急性期，血清sE-selectin水平仍显著升高（16.2±7.3 ng/ml；p<0.005）。急性期sE-selectin水平与肿瘤坏死因子-α（TNF-α）呈良好的线性相关（r2 = 0.64，p<0.01）。急性期sE-selectin水平与白细胞介素-6（IL-6）也呈良好相关（r2 = 0.54，p<0.05）。KD患者血清sE-selectin水平升高为急性血管炎与血清sE-selectin之间的关系提供了额外证据。
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