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Role of positive charges of neuropeptide Y fragments in mast cell activation.

作者信息

Mousli M, Landry Y

机构信息

Laboratoire de Neuroimmunopharmacologie, INSERM CJF-9105, Université Louis Pasteur, Illkirch, France.

出版信息

Agents Actions. 1994 Jun;41 Spec No:C41-2. doi: 10.1007/BF02007758.

DOI:10.1007/BF02007758
PMID:7526655
Abstract

The incubation of neuropeptide Y (NPY) or of NPY C-terminal fragments with rat peritoneal mast cells resulted in a dose-dependent histamine secretion (10(-9)-10(-5) M). A linear correlation between the number of net positive charges of the peptides and histamine release potencies was obtained. The histamine secretion induced by NPY fragments was inhibited by the treatment of mast cells with benzalkonium chloride and pertussis toxin indicating the involvement of G proteins.

摘要

相似文献

1
Role of positive charges of neuropeptide Y fragments in mast cell activation.
Agents Actions. 1994 Jun;41 Spec No:C41-2. doi: 10.1007/BF02007758.
2
Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. A direct effect on G proteins?
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Structure activity studies of mast cell activation and hypotension induced by neuropeptide Y (NPY), centrally truncated and C-terminal NPY analogues.神经肽Y（NPY）、中央截短型和C端NPY类似物诱导肥大细胞活化和低血压的构效关系研究。
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引用本文的文献

1
Role of G-proteins in peptidergic activation of both human and rat cutaneous mast cells.G蛋白在人及大鼠皮肤肥大细胞肽能激活中的作用。
Inflamm Res. 1995 Apr;44 Suppl 1:S26-7. doi: 10.1007/BF01674379.

本文引用的文献

1
Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets?神经肽Y相关肽及其受体——这些受体是潜在的治疗药物靶点吗？
Annu Rev Pharmacol Toxicol. 1993;33:309-52. doi: 10.1146/annurev.pa.33.040193.001521.
2
The mechanism of inhibition of alkylamines on the mast-cell peptidergic pathway.烷基胺对肥大细胞肽能途径的抑制机制。
Biochim Biophys Acta. 1993 Apr 16;1176(3):305-12. doi: 10.1016/0167-4889(93)90059-x.
3
Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide.
神经肽Y——一种与肽YY和胰多肽结构相似的新型脑肽。
Nature. 1982 Apr 15;296(5858):659-60. doi: 10.1038/296659a0.
4
Activation of rat peritoneal mast cells by substance P and mastoparan.P物质和肥大细胞脱粒肽对大鼠腹膜肥大细胞的激活作用。
J Pharmacol Exp Ther. 1989 Jul;250(1):329-35.
5
G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides.
Trends Pharmacol Sci. 1990 Sep;11(9):358-62. doi: 10.1016/0165-6147(90)90179-c.
6
Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.
J Biol Chem. 1990 Aug 25;265(24):14176-86.
7
Neuropeptide Y, peptide YY and C-terminal fragments release histamine from rat peritoneal mast cells.神经肽Y、肽YY和C末端片段可使大鼠腹膜肥大细胞释放组胺。
Br J Pharmacol. 1991 Dec;104(4):776-8. doi: 10.1111/j.1476-5381.1991.tb12505.x.
8
Structure of neuropeptide Y dimer in solution.
Eur J Biochem. 1992 May 1;205(3):1099-106. doi: 10.1111/j.1432-1033.1992.tb16878.x.