Vitali A, Ardoino S, Durante P, Ferro M A, Li Causi F, Parodi C, Sanguineti G, Gaffuri M, Paerachino M, Salvadori R P
Servizio di Anatomia Patologica, Ospedale S. Corona, Pietra Ligure (SV), Italia.
Anticancer Res. 1994 Jul-Aug;14(4A):1503-7.
PSA and PSAP were examined in 198 prostatic biopsies and correlated with PSA and PSAP serum levels evaluated before biopsies. In every type of lesion there was no relation between PSA or PSAP serum levels and their expression in biopsy specimens. PSA and PSAP staining was similar in both cancer and benign hyperplasia and lower in dysplasia, atrophy and prostatitis; while serum levels were higher in adenocarcinomas than in other lesions. A significant difference of PSAP serum levels was noted in different Gleason's grading of neoplasia, found neither with PSA serum levels/nor with PSA and PSAP tissue staining.
对198份前列腺活检样本进行了前列腺特异性抗原（PSA）和前列腺特异性酸性磷酸酶（PSAP）检测，并将其与活检前评估的血清PSA和PSAP水平进行关联分析。在每种病变类型中，血清PSA或PSAP水平与其在活检标本中的表达之间均无关联。PSA和PSAP染色在癌症和良性增生中相似，在发育异常、萎缩和前列腺炎中较低；而腺癌的血清水平高于其他病变。在肿瘤的不同Gleason分级中，PSAP血清水平存在显著差异，而PSA血清水平以及PSA和PSAP组织染色均未发现此差异。
