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沙鼠海马中bcl-2癌蛋白的增加与对缺血诱导的神经元死亡的耐受性

Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus.

作者信息

Shimazaki K, Ishida A, Kawai N

机构信息

Department of Physiology, Jichi Medical School, Tochigi-ken, Japan.

出版信息

Neurosci Res. 1994 Jul;20(1):95-9. doi: 10.1016/0168-0102(94)90026-4.

DOI:10.1016/0168-0102(94)90026-4
PMID:7527133
Abstract

We studied the expression of bcl-2 oncoprotein in the gerbil hippocampus after transient ischemia. Immunostaining using monoclonal antibody raised against bcl-2 oncoprotein revealed intense immunoreactivity in the CA1 area following 2 min of ischemia, which induced tolerance to subsequent ischemia and prevented delayed neuronal death (DND). Following ischemia for 5 min, however, bcl-2 oncoprotein immunoreactivity was decreased, reflecting neuronal death in the CA1 area. However, pretreatment with ischemia of 2 min that prevented DND due to subsequent ischemia for 5 min, showed increased immunoreactivity. On the other hand, following 1 min of ischemia which failed to induce tolerance, no increase in the bcl-2 oncoprotein was observed. The results evidenced that expression of bcl-2 oncoprotein in the CA1 area following brief ischemia is closely related to the acquisition of resistance to DND.

摘要

我们研究了短暂性脑缺血后沙鼠海马中bcl-2癌蛋白的表达。使用针对bcl-2癌蛋白产生的单克隆抗体进行免疫染色,发现在缺血2分钟后CA1区有强烈的免疫反应性,这诱导了对随后缺血的耐受性并预防了迟发性神经元死亡(DND)。然而,缺血5分钟后,bcl-2癌蛋白免疫反应性降低,反映了CA1区的神经元死亡。但是,预先进行2分钟的缺血预处理可预防因随后5分钟缺血导致的DND,其免疫反应性增加。另一方面,缺血1分钟未能诱导耐受性,未观察到bcl-2癌蛋白增加。结果证明,短暂缺血后CA1区bcl-2癌蛋白的表达与对DND的抗性获得密切相关。

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