Shepotinovskaia I V, Umanskaia N Ia, Pushkina N V
Prikl Biokhim Mikrobiol. 1994 Jul-Oct;30(4-5):709-15.
The possibility of stabilizing medicinal preparations of protein nature using the inhibitor of proteolytic enzymes, contrical (Trasilol) has been studied. On long storage, free ammonia and products of protein fragmentation accumulated in protein preparations, and the degree of amidation was reduced. This led to the decrease in biological activity of immunoglobulins and insulin. Contrical produced a stabilizing effect irrespective of the nature of protein, and because of this may find an application in pharmacy.
已经研究了使用蛋白水解酶抑制剂抑肽酶（Trasylol）来稳定蛋白质性质药物制剂的可能性。在长期储存过程中，蛋白质制剂中积累了游离氨和蛋白质片段化产物，并且酰胺化程度降低。这导致免疫球蛋白和胰岛素的生物活性下降。抑肽酶无论蛋白质的性质如何都产生稳定作用，因此可能在制药领域得到应用。
