Morozova T I, Khudzik L B
Probl Tuberk. 1993(3):27-30.
Changes in hemostasis and basic serum antiproteases (alpha 1 protease inhibitor--alpha 1-PI and alpha 2-macroglobulin--alpha 2-MG) were followed up in patients with infiltrative pulmonary tuberculosis in the destruction phase. 65 patients received chemotherapy in combination with contrykal inhalations, 63 patients were given glucocorticoid hormones and prodectin. It was found that natural protease inhibitors produced a marked clinical response, abated more rapidly thrombohemorrhagic syndrome, promoted normalization of coagulation and fibrinolysis. Replacement aerosol therapy with antiprotease agents reestablished the concentration of alpha 1-PI, but had no effect on that of alpha 2-MG. This may contribute to reparative processes in pulmonary tissue which ran without significant signs of sclerosis. The results obtained may be used by clinicians choosing methods of pathogenetic therapy.
对处于毁损期的浸润性肺结核患者的止血功能及基础血清抗蛋白酶（α1蛋白酶抑制剂——α1-PI和α2巨球蛋白——α2-MG）变化进行了随访。65例患者接受化疗并联合抑肽酶吸入治疗，63例患者给予糖皮质激素和丙种球蛋白。结果发现，天然蛋白酶抑制剂产生了显著的临床反应，更迅速地减轻了血栓出血综合征，促进了凝血和纤溶的正常化。用抗蛋白酶制剂进行替代雾化治疗可使α1-PI浓度恢复正常，但对α2-MG浓度没有影响。这可能有助于肺组织的修复过程，且该过程无明显硬化迹象。所得结果可供临床医生选择病因治疗方法时参考。
