Vacca A, Ribatti D, Roncali L, Ranieri G, Serio G, Silvestris F, Dammacco F
Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy.
Br J Haematol. 1994 Jul;87(3):503-8. doi: 10.1111/j.1365-2141.1994.tb08304.x.
Tumour growth is angiogenesis-dependent. We found a high correlation between the extent of bone marrow angiogenesis, evaluated as microvessel area, and the proliferating (S-phase) fraction of marrow plasma cells, evaluated as labelling index (LI), in patients with multiple myeloma (MM) and in those with monoclonal gammopathies of undetermined significance (MGUS). Angiogenesis itself was significantly associated with active as opposed to non-active MM and MGUS. The highest microvessel area accompanied rapidly progressive MM with the highest LI. When a cut-off value of 2% or greater of the microvessel area was used, most patients with active MM were classified correctly. The risk of active disease in patients with MM increased in parallel with the microvessel area. A causal relationship between plasma cell growth, activity phase in MM and marrow angiogenesis is suggested. Since angiogenesis proceeds in step with the enlargement of plasma cell tumours and the activity phase in MM, its measurement could be a useful prognostic marker in patients with plasma cell proliferative disorders.
肿瘤生长依赖于血管生成。我们发现，在多发性骨髓瘤（MM）患者以及意义未明的单克隆丙种球蛋白病（MGUS）患者中，以微血管面积评估的骨髓血管生成程度与以标记指数（LI）评估的骨髓浆细胞增殖（S期）分数之间存在高度相关性。血管生成本身与活动性MM和MGUS（而非非活动性MM和MGUS）显著相关。微血管面积最大的情况出现在具有最高LI的快速进展性MM中。当微血管面积的截断值为2%或更高时，大多数活动性MM患者被正确分类。MM患者中活动性疾病的风险与微血管面积平行增加。这提示了浆细胞生长、MM的活动期与骨髓血管生成之间存在因果关系。由于血管生成与浆细胞瘤的扩大以及MM的活动期同步进行，对其进行测量可能是浆细胞增殖性疾病患者有用的预后标志物。
