Lun A, Lenz F, Priem F, Brux B, Gross J, Bollmann R, Hartung J, Bartho S, Kirchmaier F, Reisinger I
Institute of Pathological and Clinical biochemistry, Universitätsklinikum Charité, Berlin, Germany.
Clin Biochem. 1994 Aug;27(4):283-7. doi: 10.1016/0009-9120(94)90031-0.
Thirty-two fetuses, six with prune-belly syndrome, seven with renal cyst, 19 with obstructive uropathy, underwent intrauterine fluid aspiration during weeks 15-37 of gestation. Fluid samples were analysed for Na, K, creatinine, urea, alpha 1-, and beta 2-microglobulin. Aspirate concentrations of sodium below 130 mmol/L and creatinine above 115 mumol/L indicate an active kidney and exclude a renal cyst. However, aspirates from fetal cysts or fetuses with obstructive uropathy showed analyte concentrations for sodium, potassium, creatinine, and urea corresponding to extracellular fluid (ECF). In conclusion fluid aspirates of fetuses with ultrasonographically detectable cystic cavities in the abdomen should be examined for sodium and creatinine to assess remaining renal function for planning of obstetric management.
32例胎儿，其中6例患有梅干腹综合征，7例患有肾囊肿，19例患有梗阻性尿路病，在妊娠15至37周期间接受了宫内羊水抽吸。对羊水样本进行钠、钾、肌酐、尿素、α1-和β2-微球蛋白分析。羊水钠浓度低于130 mmol/L且肌酐高于115 μmol/L表明肾脏活跃，可排除肾囊肿。然而，来自胎儿囊肿或患有梗阻性尿路病胎儿的羊水样本显示钠、钾、肌酐和尿素的分析物浓度与细胞外液（ECF）一致。总之，对于腹部超声可检测到囊性腔的胎儿，应检查羊水钠和肌酐，以评估剩余肾功能，为产科管理计划提供依据。
