Bellissant E, Thuillez C, Richer C, Pussard E, Giudicelli J F
Service de Pharmacologie Clinique, Hôpital de Bicĕtre, Le Kremlin, France.
J Cardiovasc Pharmacol. 1994 Sep;24(3):500-8. doi: 10.1097/00005344-199409000-00020.
The effects of single oral doses of lisinopril (5 and 20 mg) on systemic and regional hemodynamics were investigated noninvasively in a placebo-controlled, randomized, double-blind, cross-over study of 6 healthy male volunteers. Lisinopril induced a dose-dependent (significant after 20 mg) and long-lasting (< or = 8 h) decrease in mean arterial pressure (MAP, approximately 11% after 20 mg) that was related to a decrease in total peripheral resistance (TPR), because simultaneously heart rate (HR) and cardiac output (CO) were unchanged. Brachial artery flow (+42 and +47% after 5 and 20 mg, respectively) and diameter (+8 and +9%) increased significantly, whereas brachial vascular resistance (-31 and -38%) decreased significantly from 2 to 8 h after drug intake. Common carotid artery flow (+20 and +24%) also increased significantly, whereas corresponding resistance (-18 and -26%) decreased significantly during the same period. Finally, CO was significantly redistributed toward the brachial and, to a lesser extent, the carotid vascular beds after both doses of lisinopril. We conclude that in healthy subjects lisinopril, at non- or slightly hypotensive doses, dilates both arterioles and large arteries and that this vasodilation is not homogeneous, affecting preferentially the brachial rather than the carotid vascular bed.
在一项针对6名健康男性志愿者的安慰剂对照、随机、双盲、交叉研究中，采用无创方法研究了单次口服赖诺普利（5毫克和20毫克）对全身和局部血流动力学的影响。赖诺普利可引起剂量依赖性（20毫克后显著）且持久（≤8小时）的平均动脉压降低（20毫克后约为11%），这与总外周阻力降低有关，因为同时心率（HR）和心输出量（CO）未发生变化。肱动脉血流（5毫克和20毫克后分别增加42%和47%）和直径（分别增加8%和9%）显著增加，而肱血管阻力在服药后2至8小时显著降低（分别降低31%和38%）。颈总动脉血流（分别增加20%和24%）也显著增加，而同期相应阻力（分别降低18%和26%）显著降低。最后，两种剂量的赖诺普利给药后，心输出量均显著重新分布至肱血管床，在较小程度上也重新分布至颈动脉血管床。我们得出结论，在健康受试者中，非降压或轻度降压剂量的赖诺普利可使小动脉和大动脉均扩张，且这种血管扩张并非均匀一致，优先影响肱血管床而非颈动脉血管床。
