Oesterling J E, Girman C J, Panser L A, Chute C G, Barrett D M, Guess H A, Lieber M M
Department of Urology, Mayo Clinic, Rochester, Minnesota.
Prog Clin Biol Res. 1994;386:125-39.
This investigation is unique in that is the first study to use a large number of randomly chosen men from the community to establish the relationship between: 1) urinary flow rate and voided volume, 2) urinary flow rate and patient age, 3) voided volume and patient age, and 4) the time to achieve peak urinary flow rate and patient age. The results clearly indicate that both the peak and mean urinary flow rate decreases with advancing age. The voided volume also diminishes with increasing age. The time required to achieve the peak urinary flow rate, however, appears to be independent of the patient's age. Irrespective of age, approximately 9 seconds are required to achieve the maximum urinary flow rate. Because the urinary flow rate is dependent upon both the quantity of urine voided and the patient's age, it is necessary to account for the influence of both parameters when establishing the "normal range" for peak urinary flow rate. To this end, nomograms estimating the peak urinary flow rate percentile as a function of voided volume and patient age have been generated and are included in this report. These nomograms, based on a large, randomly selected population, should make peak urinary flow rate a more reliable diagnostic modality for assessing bladder outlet obstruction. They also should be most useful to the practicing clinician when interpreting the results of a peak urinary flow rate determination for a patient presenting with symptoms of prostatism.
这项研究具有独特之处，它是第一项从社区中随机选取大量男性来确立以下关系的研究：1）尿流率与排尿量；2）尿流率与患者年龄；3）排尿量与患者年龄；4）达到尿流率峰值的时间与患者年龄。结果清楚地表明，尿流率峰值和平均尿流率均会随着年龄的增长而下降。排尿量也会随着年龄的增加而减少。然而，达到尿流率峰值所需的时间似乎与患者年龄无关。无论年龄大小，达到最大尿流率大约需要9秒。由于尿流率取决于排尿量和患者年龄两者，因此在确立尿流率峰值的“正常范围”时，有必要考虑这两个参数的影响。为此，已生成了根据排尿量和患者年龄估算尿流率峰值百分位数的列线图，并包含在本报告中。这些基于大量随机选择人群的列线图，应会使尿流率峰值成为评估膀胱出口梗阻更可靠的诊断方法。当临床医生解读患有前列腺增生症状患者的尿流率峰值测定结果时，它们也应会对临床医生最为有用。
