Husain S, Silvers D N, Halperin A J, McNutt N S
Department of Pathology, College of Physicians and Surgeons, Columbia-Presbyterian Medical Center, New York, New York.
Am J Dermatopathol. 1994 Oct;16(5):496-503. doi: 10.1097/00000372-199410000-00004.
Neurothekeoma, a benign cutaneous lesion of probable nerve sheath origin, is divided histologically into two subtypes--myxoid and cellular. However, we believe that neurothekeoma encompasses a wider spectrum of lesions, with the myxoid and cellular subtypes falling at either end of the morphologic spectrum. Because the cellular variant of neurothekeoma sometimes resembles melanoma, it presents a difficult diagnostic problem. We report the histologic and immunohistochemical findings in 14 cases of neurothekeoma and review the findings in 35 additional cases from the literature. A detailed analysis of the histologic spectrum is also included. When examined by immunostains, only the myxoid variants of neurothekeoma stain positively for S-100 protein. We conclude that when the histological differential diagnosis is between cellular neurothekeoma and melanoma, an S-100-positive lesion should be regarded as melanoma.
神经鞘黏液瘤是一种可能起源于神经鞘的良性皮肤病变，在组织学上分为两种亚型——黏液样型和细胞型。然而，我们认为神经鞘黏液瘤涵盖了更广泛的病变范围，黏液样型和细胞型亚型处于形态学谱的两端。由于神经鞘黏液瘤的细胞型有时类似于黑色素瘤，因此它提出了一个诊断难题。我们报告了14例神经鞘黏液瘤的组织学和免疫组化结果，并复习了文献中另外35例的结果。还包括对组织学谱的详细分析。通过免疫染色检查时，只有神经鞘黏液瘤的黏液样亚型对S-100蛋白呈阳性染色。我们得出结论，当组织学鉴别诊断是在细胞型神经鞘黏液瘤和黑色素瘤之间时，S-100阳性病变应被视为黑色素瘤。
