DeBroff B M, Thoft R A
Eye and Ear Institute, University of Pittsburgh, Pa.
J Refract Corneal Surg. 1994 Jul-Aug;10(4):428-32.
Results of penetrating keratoplasty in iridocorneal endothelial syndrome have been considered favorable based on past studies; however, documented results in eyes specifically with essential iris atrophy are lacking.
A retrospective study was performed to evaluate all patients at the University of Pittsburgh with essential iris atrophy who had undergone penetrating keratoplasty for corneal decompensation over 21 years (1971-1992).
Penetrating keratoplasty had been performed on six eyes with essential iris atrophy for corneal decompensation. All eyes postoperatively had evidence of persistent anterior uveitis resistant to corticosteroid treatment with one or more episodes of graft reaction. Five of the six eyes (83.3%) ultimately went on to graft failure. Two of the six eyes (33.3%) rejected grafts on two separate occasions.
Penetrating keratoplasty in essential iris atrophy was frequently associated with chronic anterior uveitis and immunologic graft failure.
根据以往研究，虹膜角膜内皮综合征行穿透性角膜移植术的结果被认为是良好的；然而，缺乏专门针对原发性虹膜萎缩眼的记录结果。
进行一项回顾性研究，以评估匹兹堡大学21年间（1971 - 1992年）因角膜失代偿而接受穿透性角膜移植术的所有原发性虹膜萎缩患者。
对6只原发性虹膜萎缩眼因角膜失代偿进行了穿透性角膜移植术。所有术眼术后均有持续性前葡萄膜炎的证据，对皮质类固醇治疗耐药，且有一次或多次移植反应。6只眼中的5只（83.3%）最终移植失败。6只眼中的2只（33.3%）在两个不同的时间发生移植排斥。
原发性虹膜萎缩行穿透性角膜移植术常伴有慢性前葡萄膜炎和免疫性移植失败。
