Luo Z, Zeng H, Sun G, Sun Y, He L, Chen C, Jiang J
Hua Xi Yi Ke Da Xue Xue Bao. 1994 Jun;25(2):218-21.
Forty-six patients with acute arteriosclerostic cerebral infarction were randomly divided into two groups: control group and treatment group. Each of them included 23 patients respectively. The patients in the control group were given Dextran-40 but the ones in the treatment group were given the mixture of Zuzhongping. The course of treatment was 3 weeks. It was found that there was a significant difference (P < 0.01) in the score percentage, before and after treatment of neurological defects, between the control group and the treatment group, and the former (29.70 +/- 33.52) was much lower than the latter (45.40 +/- 27.60). The total curative rate of the treatment group (87.0%, 20/23) was significantly higher than that of the control group (60.9%, 14/23). There was an obviously prolonged KPTT (kaolin partial thromboplastin time) value and a decreased Fb (fibrinogen) level in the treatment group. Before treatment they were 32.43 +/- 4.03 sec and 6.18 +/- 1.77 g/L respectively, but after treatment, 52.96 +/- 10.50 sec and 4.5 +/- 0.95 g/L respectively. The authors suggest that the significant therapeutic efficacy of Zuzhongping in the patients with acute arteriosclerostic cerebral infarction is related to its action of anticoagulation, modification of PGI2 and TXA2 level in the body, decreased blood Fb level, hyperglycemia, etc.
46例急性动脉硬化性脑梗死患者随机分为两组：对照组和治疗组，每组各23例。对照组患者给予低分子右旋糖酐，治疗组患者给予逐瘀平合剂。疗程为3周。结果发现，对照组与治疗组治疗前后神经功能缺损评分百分数有显著差异（P<0.01），前者（29.70±33.52）明显低于后者（45.40±27.60）。治疗组总有效率（87.0%，20/23）明显高于对照组（60.9%，14/23）。治疗组白陶土部分凝血活酶时间（KPTT）值明显延长，纤维蛋白原（Fb）水平降低。治疗前分别为32.43±4.03秒和6.18±1.77克/升，治疗后分别为52.96±10.50秒和4.5±0.95克/升。作者认为，逐瘀平对急性动脉硬化性脑梗死患者有显著治疗效果，与其抗凝作用、调节体内前列环素（PGI2）和血栓素A2（TXA2）水平、降低血液Fb水平、降血糖等作用有关。
