Chapman V, Dickenson A H, Tjølsen A
Department of Pharmacology, University College London, UK.
Neurosci Lett. 1994 Aug 29;178(1):90-4. doi: 10.1016/0304-3940(94)90297-6.
Intrathecal NMDA (5 ng) facilitated wind-up but not C-fibre evoked responses, whereas 50 ng facilitated C-fibre and A delta-fibre evoked responses but not wind-up of convergent dorsal horn neurones in the halothane anaesthetized rat. Higher doses of NMDA and SP (10-500 ng) were without effect. Co-administered SP (10 ng) with NMDA (5 ng) facilitated A delta-fibre evoked responses and wind-up. Excitatory amino acid and peptide interactions are discussed.
鞘内注射NMDA（5纳克）可增强wind-up现象，但不影响C纤维诱发反应，而50纳克则可增强C纤维和Aδ纤维诱发反应，但不影响氟烷麻醉大鼠中汇聚背角神经元的wind-up现象。更高剂量的NMDA和P物质（10 - 500纳克）则无此作用。联合给予P物质（10纳克）和NMDA（5纳克）可增强Aδ纤维诱发反应和wind-up现象。文中讨论了兴奋性氨基酸和肽之间的相互作用。
