Chisholm G D, Hedlund P O, Adolfsson J, Denis L J, Friberg S, Johansson J E, Peeling B
Dept. of Urology, University of Edinburgh, U.K.
Scand J Urol Nephrol Suppl. 1994;162:107-14; discussion 115-27.
The TNM working group acknowledges the multinational agreement reached in the 1992 TNM classification, but nevertheless gives some suggestions for modifications. The main interest of the group has been to evaluate parameters suitable for further ramification of the system. The group found that parameters such as DNA ploidy, PSA, nuclear roundness factor, are not yet ready for this purpose. Grade is an established parameter and should be incorporated into the TNM-categories of localized disease. In metastatic disease a number of parameters are available to subdivide this category according to prognosis, and these will be more uniformly and extensively studied in the several large trials that are now in progress.
