Terris M K, Haney D J, Johnstone I M, McNeal J E, Stamey T A
Department of Urology, Stanford University, California.
Urology. 1995 Jan;45(1):75-80. doi: 10.1016/s0090-4295(95)96858-x.
Prostate-specific antigen (PSA) levels, transrectal ultrasound, and systematic sextant biopsies have each shown limited ability to predict prostate cancer volume. In combination, these studies may allow more accurate estimation of volume and prognosis.
One hundred twenty-four patients were evaluated prior to radical prostatectomy. Interactive stepwise multiple regression and separate logistic regression analysis were performed for prediction of prostate cancer volume and volume range.
The cancer volumes calculated correlated with the volumes in the radical prostatectomy specimens with R2 of 0.76. Cancers were predicted to be in the volume range associated with poor prognosis (more than 12 cc) or clinically insignificant cancer (less than 1.0 cc) with bias corrected error rates of 5.3% and 10%, respectively.
The formula for prediction of cancer volume correlates well with actual cancer volume in 92 patients but is not adequate to predict volume for an individual patient. The formulas for prediction of volume range show promising predictive ability and may be useful if the extent of disease is unclear.
前列腺特异性抗原（PSA）水平、经直肠超声检查和系统性六分区活检各自在预测前列腺癌体积方面能力有限。综合这些研究可能会更准确地估计体积和预后。
对124例患者在根治性前列腺切除术之前进行评估。采用交互式逐步多元回归和单独的逻辑回归分析来预测前列腺癌体积和体积范围。
计算出的癌体积与根治性前列腺切除标本中的体积相关，R2为0.76。预测癌症处于与预后不良相关的体积范围（超过12立方厘米）或临床意义不显著的癌症（小于1.0立方厘米），偏差校正错误率分别为5.3%和10%。
预测癌体积的公式与92例患者的实际癌体积相关性良好，但不足以预测个体患者的体积。预测体积范围的公式显示出有前景的预测能力，并且在疾病范围不明确时可能有用。
