Hara K, Komatsu H, Tsutsumi N, Ujiie A, Ikeda S, Kobayashi T, Kudo I, Inoue K
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Biol Pharm Bull. 1994 Aug;17(8):1121-3. doi: 10.1248/bpb.17.1121.
Anti-allergic drugs, tranilast and azelastine, were examined for their effects on lysophosphatidylserine (lysoPS)-dependent histamine release from rat mast cells. Although both compounds suppressed the histamine release in a dose-dependent manner, the inhibition was affected by lysoPS concentration differently. In the presence of an increasing concentration of lysoPS, the suppressive effect of tranilast decreased. The inhibition by azelastine, however, was independent of the concentration of lysoPS. The findings suggest that these two drugs inhibit lysoPS-depedent histamine release through essentially different routes.
研究了抗组胺药曲尼司特和氮卓斯汀对大鼠肥大细胞中溶血磷脂酰丝氨酸（lysoPS）依赖性组胺释放的影响。尽管这两种化合物均以剂量依赖性方式抑制组胺释放，但抑制作用受lysoPS浓度的影响不同。在lysoPS浓度增加的情况下，曲尼司特的抑制作用降低。然而，氮卓斯汀的抑制作用与lysoPS浓度无关。这些发现表明，这两种药物通过基本不同的途径抑制lysoPS依赖性组胺释放。
