广谱抗惊厥药洛雷唑在大鼠中的抗惊厥作用可能部分由5-羟色胺介导：一项微透析研究。

The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study.

作者信息

Dailey J W, Seo D O, Yan Q S, Ko K H, Jo M, Jobe P C

机构信息

Department of Basic Sciences, University of Illinois College of Medicine at Peoria 61656.

出版信息

Neurosci Lett. 1994 Sep 12;178(2):179-83. doi: 10.1016/0304-3940(94)90754-4.

DOI:10.1016/0304-3940(94)90754-4

PMID:7529909

Abstract

Loreclezole is an experimental anticonvulsant drug. We found previously that several established anticonvulsants increase extracellular serotonin as measured by microdialysis. We have concluded that the increase in extracellular serotonin and the anticonvulsant effect produced by these anticonvulsant drugs are related in a cause and effect manner. To determine if anticonvulsant doses of loreclezole increase extracellular serotonin, we determined anticonvulsant dose-response relationships in genetically epilepsy-prone rats (GEPRs). Then, we administered ED99 doses of loreclezole to GEPRs and determined the effect on extracellular serotonin as measured by microdialysis in the striatum. We conclude that loreclezole produces a dose-related anticonvulsant effect in GEPRs and that anticonvulsant doses of loreclezole increase extracellular serotonin in these animals.

摘要

洛雷唑是一种实验性抗惊厥药物。我们之前发现，通过微透析测量，几种已有的抗惊厥药物会增加细胞外5-羟色胺水平。我们得出结论，这些抗惊厥药物所产生的细胞外5-羟色胺增加与抗惊厥作用存在因果关系。为了确定抗惊厥剂量的洛雷唑是否会增加细胞外5-羟色胺，我们在遗传性癫痫易感大鼠（GEPRs）中确定了抗惊厥剂量-反应关系。然后，我们给GEPRs施用洛雷唑的ED99剂量，并通过微透析测定纹状体中细胞外5-羟色胺的变化。我们得出结论，洛雷唑在GEPRs中产生剂量相关的抗惊厥作用，且抗惊厥剂量的洛雷唑会增加这些动物的细胞外5-羟色胺水平。