Agrawal D, Subramoniam A, Afaq F
Industrial Toxicology Research Centre, Lucknow, India.
Toxicology. 1995 Jan 6;95(1-3):135-40. doi: 10.1016/0300-483x(94)02898-5.
Single exposure of rats to hexachlorocyclohexane (100 mg/kg) did not cause any significant change in phosphoinositide levels in rat erythrocyte membrane and cerebrum (fore brain) 2 or 24 h after exposure. However, the phosphoinositide turnover and generation of second messengers from phosphoinositides were increased in the treated erythrocyte membranes as judged from a marked increase in the incorporation of [2-3H]inositol into phosphoinositides 24 h after the treatment. A significant decrease in phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2) was observed in the erythrocyte membrane and cerebrum of rats repeatedly exposed to the pesticide for 3 or 6 months. This drastic reduction in phosphoinositide levels suggests adverse effects on vital membrane and cell functions modulated by phosphoinositides.
大鼠单次暴露于六氯环己烷（100毫克/千克）后，在暴露后2小时或24小时，大鼠红细胞膜和大脑（前脑）中的磷酸肌醇水平未发生任何显著变化。然而，从处理后24小时[2-3H]肌醇掺入磷酸肌醇的显著增加判断，处理后的红细胞膜中磷酸肌醇周转率和磷酸肌醇产生的第二信使增加。在反复接触该农药3个月或6个月的大鼠的红细胞膜和大脑中，观察到磷脂酰肌醇（PI）、磷脂酰肌醇4-磷酸（PIP）和磷脂酰肌醇4,5-二磷酸（PIP2）显著减少。磷酸肌醇水平的这种急剧下降表明对由磷酸肌醇调节的重要膜和细胞功能产生了不利影响。
