Lyashenko A A
Institute of biomedical chemistry, Moscow, Russia.
Biochem Biophys Res Commun. 1995 Jan 17;206(2):736-41. doi: 10.1006/bbrc.1995.1104.
Comparative studies of primary sequences of nitric oxide synthase (NOS) and pterin-dependent enzymes has shown that the biopterin-dependent site of NOS is localized between the regions responsible for calmodulin and FMN binding. On the example of NOS from rat brain it was demonstrated that this biopterin-binding site is located in the region 750-769. Pairwise alignment of amino acids sequences of NOS from rat brain and rat xantine dehydrogenase revealed that the two proteins are 39.7% identical.
一氧化氮合酶（NOS）与蝶呤依赖性酶的一级序列比较研究表明，NOS的生物蝶呤依赖性位点位于负责钙调蛋白和黄素单核苷酸（FMN）结合的区域之间。以大鼠脑NOS为例，已证明该生物蝶呤结合位点位于750 - 769区域。大鼠脑NOS和大鼠黄嘌呤脱氢酶的氨基酸序列两两比对显示，这两种蛋白质的同源性为39.7%。
