Solodkov A P, Bozhko A P
Fiziol Zh Im I M Sechenova. 1994 Apr;80(4):65-71.
The effect of saponin and blockade of the nitrogen oxide upon the coronary endothelium was found in rats subjected to a 6-hrs stress. The damage of the endothelium and the blockade abolished the stressor-induced increase in the coronary blood flow velocity. The index of autoregulation and the latter's efficiency, however, remained the same. Preliminary administration of L-arginine prevented the effect of NG-monomethyl-L-arginine upon the coronary flow in the isolated hearts of rats subjected to stress. The post-stressor increase in the coronary blood flow seems to be due to an increase in releasing the nitrogen oxide from the coronary vessels' endotheliocytes.
在遭受6小时应激的大鼠中发现了皂苷和一氧化氮阻断对冠状动脉内皮的影响。内皮损伤和阻断消除了应激源诱导的冠状动脉血流速度增加。然而，自动调节指数及其效率保持不变。预先给予L-精氨酸可防止NG-单甲基-L-精氨酸对遭受应激的大鼠离体心脏冠状动脉血流的影响。应激后冠状动脉血流增加似乎是由于冠状动脉血管内皮细胞释放一氧化氮增加所致。
