Eken P, de Vries L S, van der Graaf Y, Meiners L C, van Nieuwenhuizen O
Department of Child Neurology, Whilhelmina Children's Hospital, Utrecht, The Netherlands.
Dev Med Child Neurol. 1995 Jan;37(1):41-55. doi: 10.1111/j.1469-8749.1995.tb11931.x.
The relationship between the degree of cerebral visual impairment, established using the acuity card procedure, and the extent of neurological sequelae was assessed in 65 at-risk neonates in a prospective follow-up study. MRI and CT scans were performed in all infants with severe neurological sequelae. 11 of 12 children with an acuity at or below the 10th centile at 18 months developed cerebral palsy: the underlying condition was extensive cystic leukomalacia in all. An acuity above the 10th centile was no guarantee of normal development, as 10 out of 52 such infants developed cerebral palsy. MRI and CT scans showed that periventricular high signal intensity in the occipital area was a non-specific finding with regard to visual function. Extensive periventricular white matter loss and involvement of the striate/parastriate cortex was found in the most severely visually impaired infants.
在一项前瞻性随访研究中，对65名高危新生儿评估了使用视力卡片程序确定的脑性视觉障碍程度与神经后遗症程度之间的关系。对所有患有严重神经后遗症的婴儿进行了MRI和CT扫描。12名18个月时视力处于或低于第10百分位的儿童中有11名患脑性瘫痪：所有患儿的潜在病症均为广泛性囊性脑白质软化。视力高于第10百分位并不能保证正常发育，因为52名此类婴儿中有10名患脑性瘫痪。MRI和CT扫描显示，枕叶区域的脑室周围高信号强度在视觉功能方面是非特异性表现。在视觉障碍最严重的婴儿中发现了广泛的脑室周围白质丢失和纹状/旁纹状皮质受累。
