Hirokawa M, Manabe T, Sugihara K
Department of Pathology, Kawasaki Medical School, Okayama.
Jpn J Clin Oncol. 1994 Dec;24(6):336-9.
We report a case of parachordoma occurring in the buttock of a 43-year-old man, and review 20 cases of parachordoma reported in the English literature. The tumor in our case was grossly 3 cm in dimension, solid, lobulated and grayish-white in color. Microscopically, the tumor consisted of epithelioid and spindle cells, and fibromyxoid stroma. The epithelioid cells were immunohistochemically positive for vimentin, S-100 protein, neuron-specific enolase, keratin, carcinoembryonic antigen and epithelial membrane antigen, and negative for HMB45. These findings are similar to those for chordoma rather than extraskeletal myxoid chrondrosarcoma. Although the etiopathogenesis of parachordoma remains obscure, Schwann cells or some other neuron-related cell origin are suspected.
我们报告了一例发生在一名43岁男性臀部的副脊索瘤病例，并回顾了英文文献中报道的20例副脊索瘤病例。我们病例中的肿瘤大体直径为3 cm，实体性，分叶状，灰白色。显微镜下，肿瘤由上皮样细胞、梭形细胞和纤维黏液样基质组成。上皮样细胞免疫组化显示波形蛋白、S-100蛋白、神经元特异性烯醇化酶、角蛋白、癌胚抗原和上皮膜抗原呈阳性，而HMB45呈阴性。这些发现与脊索瘤相似，而非骨外黏液样软骨肉瘤。尽管副脊索瘤的病因仍不清楚，但怀疑其起源于施万细胞或其他一些与神经元相关的细胞。
