Caruso A, Pellati A, Bosi G, Arena N, Stabellini G
Institute of Histology and General Embryology, University of Ferrara, Italy.
Eur J Histochem. 1994;38(3):245-52.
The administration of bis-cyclohexylammonium sulphate (BCHS), an inhibitor of spermidine synthase, to cultured chick embryo fibroblasts provoked alterations in cell morphology, a marked disorganization of microfilaments and changes in microtubule network structure. In addition, the rate of microtubule reappearance, after disrupting them with colchicine, was impaired by BCHS. These responses to BCHS were prevented by spermidine addition, which thus suggests an involvement of spermidine in microtubule and microfilament organization.
向培养的鸡胚成纤维细胞施用亚精胺合酶抑制剂硫酸双环己铵（BCHS），会引发细胞形态改变、微丝显著紊乱以及微管网络结构变化。此外，用秋水仙碱破坏微管后，BCHS会损害微管重新出现的速率。添加亚精胺可防止对BCHS的这些反应，因此表明亚精胺参与了微管和微丝的组织形成。
