• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4.

作者信息

Karanam B V, Vincent S H, Newton D J, Wang R W, Chiu S H

机构信息

Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ.

出版信息

Drug Metab Dispos. 1994 Sep-Oct;22(5):811-4.

PMID:7530623
Abstract
摘要

相似文献

1
FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4.FK506在人肝微粒体中的代谢：对除CYP3A4之外的细胞色素P450同工酶参与情况的研究
Drug Metab Dispos. 1994 Sep-Oct;22(5):811-4.
2
Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.鉴定人肝微粒体中负责代谢大麻二酚的细胞色素 P450 酶。
Life Sci. 2011 Aug 1;89(5-6):165-70. doi: 10.1016/j.lfs.2011.05.018. Epub 2011 Jun 16.
3
Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA.细胞色素P450同工酶3A4和2B6参与了噻替派在体外代谢为人乙基硫替派的过程。
Cancer Chemother Pharmacol. 2002 Jun;49(6):461-7. doi: 10.1007/s00280-002-0453-3. Epub 2002 Apr 23.
4
Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism.细胞色素P-450同工酶之间对NADPH-细胞色素P-450氧化还原酶的竞争影响药物代谢。
J Pharmacol Exp Ther. 1999 May;289(2):661-7.
5
Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.人细胞色素P450 3A4在醋酸甲羟孕酮代谢中的作用。
Clin Cancer Res. 2000 Aug;6(8):3297-303.
6
Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.体外人类氟烷还原代谢由细胞色素P450 2A6和3A4催化。
Drug Metab Dispos. 1996 Sep;24(9):976-83.
7
In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism.
Arch Biochem Biophys. 1992 May 1;294(2):454-60. doi: 10.1016/0003-9861(92)90711-5.
8
Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.1,8-桉叶素（一种源自多苞桉的单萜环醚）在大鼠和人肝微粒体中被细胞色素P450 3A酶氧化。
Drug Metab Dispos. 2001 Feb;29(2):200-5.
9
In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.钙调蛋白拮抗剂DY-9760e（3-[2-[4-(3-氯-2-甲基苯基)-1-哌嗪基]乙基]-5,6-二甲氧基-1-(4-咪唑基甲基)-1H-吲唑二盐酸盐3.5水合物）在人肝微粒体中的体外代谢：细胞色素P450参与非典型动力学及潜在药物相互作用
Drug Metab Dispos. 2005 Nov;33(11):1628-36. doi: 10.1124/dmd.105.004903. Epub 2005 Jul 27.
10
Stereoselective metabolism of endosulfan by human liver microsomes and human cytochrome P450 isoforms.硫丹在人肝微粒体和人细胞色素P450同工酶中的立体选择性代谢。
Drug Metab Dispos. 2006 Jul;34(7):1090-5. doi: 10.1124/dmd.105.009134. Epub 2006 Mar 31.

引用本文的文献

1
External assessment and refinement of a population pharmacokinetic model to guide tacrolimus dosing in pediatric heart transplant.评估和完善群体药代动力学模型以指导儿童心脏移植中他克莫司的给药剂量。
Pharmacotherapy. 2023 Jul;43(7):650-658. doi: 10.1002/phar.2836. Epub 2023 Jun 22.
2
Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism.肾移植受者中他克莫司及其主要代谢产物的浓度与糖尿病和细胞色素P450 3A基因多态性的关系。
Xenobiotica. 2013 Jul;43(7):641-9. doi: 10.3109/00498254.2012.752118. Epub 2013 Jan 2.
3
Microbial Demethylation of Immunosuppressant FK-506: Isolation of 31-O-FK-506-Specific Demethylase Showing Cytochrome P-450 Characteristics from Streptomyces rimosus MA187.
微生物对免疫抑制剂 FK-506 的去甲基化：从嗜热链霉菌 MA187 中分离出具有细胞色素 P-450 特征的特异性 31-O-FK-506 去甲基酶。
Appl Environ Microbiol. 1995 Oct;61(10):3544-8. doi: 10.1128/aem.61.10.3544-3548.1995.
4
Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation.他克莫司在实体器官移植中的临床药代动力学与药效学
Clin Pharmacokinet. 2004;43(10):623-53. doi: 10.2165/00003088-200443100-00001.
5
A comparison of the pharmacokinetics of tacrolimus and microemulsified cyclosporin in paediatric renal transplant recipients.他克莫司与微乳化环孢素在儿童肾移植受者中的药代动力学比较。
Eur J Clin Pharmacol. 2004 Aug;60(6):421-6. doi: 10.1007/s00228-004-0773-9. Epub 2004 Jul 1.
6
Gene expression of cytochromes P450 in liver transplants over time.肝脏移植中细胞色素P450的基因表达随时间的变化。
Eur J Clin Pharmacol. 2004 Aug;60(6):413-20. doi: 10.1007/s00228-004-0786-4. Epub 2004 Jun 10.
7
Mechanisms of clinically relevant drug interactions associated with tacrolimus.与他克莫司相关的临床显著药物相互作用机制。
Clin Pharmacokinet. 2002;41(11):813-51. doi: 10.2165/00003088-200241110-00003.
8
Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.抗真菌药物对氧化药物代谢的影响：临床相关性。
Clin Pharmacokinet. 2000 Feb;38(2):111-80. doi: 10.2165/00003088-200038020-00002.
9
Clinical pharmacokinetics of tacrolimus.他克莫司的临床药代动力学
Clin Pharmacokinet. 1995 Dec;29(6):404-30. doi: 10.2165/00003088-199529060-00003.
10
Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber.大环内酯类免疫抑制剂他克莫司在尤斯灌流小室中经猪肠黏膜的代谢情况
Br J Pharmacol. 1996 Apr;117(8):1730-4. doi: 10.1111/j.1476-5381.1996.tb15346.x.