咔啉甲基衍生物在沙门氏菌中的致突变性。
Mutagenicity of carboline methyl derivatives in Salmonella.
作者信息
Rahden-Staroń I, Peczyńska-Czoch W, Kaczmarek L
机构信息
Department of Biochemistry, Medical School, Warsaw, Poland.
出版信息
Acta Microbiol Pol. 1994;43(2):247-50.
PMID:7530899
Abstract
A series of linear, methyl-substituted derivatives of 5H-indolo[2,3-b] quinolines was tested for mutagenic activity with the battery of Ames tester strains. Mutagenic activity of indoloquinolones was strongly influenced by the position and a number of methyl groups. All compounds tested, with one exception, act like frame-shift mutagens. Only two compounds among them were mutagenic in the strain detecting oxidative and cross-linking mutagens.
摘要
用艾姆斯试验菌株组对一系列5H-吲哚并[2,3 - b]喹啉的线性甲基取代衍生物进行了诱变活性测试。吲哚喹诺酮的诱变活性受甲基的位置和数量的强烈影响。除一个例外，所有测试的化合物都表现为移码诱变剂。其中只有两种化合物在检测氧化和交联诱变剂的菌株中具有诱变作用。
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