Broggi G, Franzini A, Cajola L, Pluchino F
Department of Neurosurgery, Istituto Nazionale Neurologico C. Besta, Milano, Italy.
Pediatr Neurosurg. 1994;21 Suppl 1:21-3. doi: 10.1159/000120857.
In vitro determination of 3H-thymidine labeling index (LI%) was carried out in craniopharyngiomas from 16 patients submitted to repeated surgical procedures. This study showed a poor correlation between LI% values and prognosis, but allowed to detect a high LI% variation in the same tumor investigated in serial different times. The spatial distribution of S-phase proliferative cells in squamous epithelium of cystic components suggests a rationale for intracavitary treatment of cystic and mixed craniopharyngioma and may help explain its success.
