Babarykin D A, Bauman V K
Latvian Medical Academy, Riga.
Fiziol Zh Im I M Sechenova. 1994 Jul;80(7):88-98.
The effect of vitamin D3 and its two metabolites 1,25(OH)2D3 and 24,25(OH)2D3 on the metabolism of heavy metals--Sr, Pb and Cd was studied. The experiments were carried out on chickens, the heavy metals were added to the chicken's ration. The results obtained demonstrated that vitamin D3 caused accumulation of those metals in tissues and their toxicity in organisms. When increasing the vitamin dose from 200 to 500 IU on 1 kg of ration that tendency was being heightened. On the three steroids which had been studied the metabolite 1,25(OH)2D3 displayed the greatest activity in accumulating metals in tissues, Pb in particular. The effect of 24,25(OH)2D3 on the indices being studied was comparable with that of vitamin D3.
研究了维生素D3及其两种代谢产物1,25(OH)2D3和24,25(OH)2D3对重金属——锶、铅和镉代谢的影响。实验以鸡为对象，将重金属添加到鸡的日粮中。所得结果表明，维生素D3会导致这些金属在组织中蓄积及其在生物体中的毒性。当每千克日粮中维生素剂量从200国际单位增加到500国际单位时，这种趋势会增强。在所研究的三种类固醇中，代谢产物1,25(OH)2D3在组织中蓄积金属方面表现出最大活性，尤其是铅。24,25(OH)2D3对所研究指标的影响与维生素D3相当。
