Nagata S
Osaka Bioscience Institute, Japan.
Philos Trans R Soc Lond B Biol Sci. 1994 Aug 30;345(1313):281-7. doi: 10.1098/rstb.1994.0107.
Homeostasis in vertebrates is tightly regulated by not only proliferation and differentiation of cells, but also cell death or apoptosis (Ellis et al. 1991; Raff 1992). Many cytokines bind to their respective receptors to regulate proliferation and differentiation of cells. Our recent studies on the Fas ligand and Fas indicate that they work respectively as a death factor and its receptor and suggest that, in some cases, cell death or apoptosis is regulated by cytokines and their receptors. Here, I present the summary of the Fas/Fas ligand system which has been studied in my laboratory over the past 5 years, and I will discuss its physiological roles.
脊椎动物体内的稳态不仅受到细胞增殖和分化的严格调控，还受到细胞死亡或凋亡的调控（埃利斯等人，1991年；拉夫，1992年）。许多细胞因子与其各自的受体结合，以调节细胞的增殖和分化。我们最近对Fas配体和Fas的研究表明，它们分别作为死亡因子及其受体发挥作用，并表明在某些情况下，细胞死亡或凋亡受细胞因子及其受体的调控。在此，我将概述过去5年在我的实验室中对Fas/Fas配体系统的研究，并讨论其生理作用。
