细胞外基质对乳腺上皮细胞中ICE及细胞凋亡的抑制作用
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.
作者信息
Boudreau N, Sympson C J, Werb Z, Bissell M J
机构信息
Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720.
出版信息
Science. 1995 Feb 10;267(5199):891-3. doi: 10.1126/science.7531366.
Abstract
Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to beta 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1 beta converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.
摘要
细胞凋亡（程序性细胞死亡）在发育和组织再生中起主要作用。研究表明，基底膜细胞外基质（ECM）而非纤连蛋白或胶原蛋白，在组织培养和体内均能抑制乳腺上皮细胞的凋亡。抗β1整合素抗体或基质溶解素-1（可降解ECM）的过表达可诱导细胞凋亡。白细胞介素-1β转化酶（ICE）的表达与ECM的丧失相关，ICE活性抑制剂可防止细胞凋亡。这些结果表明，ECM通过对ICE表达的整合素依赖性负调控来调节乳腺上皮细胞的凋亡。
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