Kobayashi S, Haba R, Hirakawa E, Yamadori I, Miki H, Ohmori M
First Department of Pathology, Kagawa Medical School, Japan.
Acta Cytol. 1995 Jan-Feb;39(1):118-24.
Cytodiagnosis is a useful adjunct to frozen section diagnosis of brain tumors during surgery and has been applied in many pathology laboratories. Although anaplastic (malignant) meningiomas are not extremely rare tumors, their cytologic features have not been well described. Cytologic details of anaplastic meningioma, papillary meningioma with a fibroblastic component and anaplastic angiomatous meningioma are presented. Papillary meningioma showed atypical cell clusters having a close relation to mature endothelial cells and that corresponded to papillary proliferation. Other cell clusters of this tumor showed an ordinary fibroblastic pattern with coarse cytoplasmic filaments and necrotic changes in the cytoplasm. Anaplastic angiomatous meningioma exhibited loose cell clusters. Some of them had coarse cytoplasmic filaments, and others were similar to epithelial cells in origin. Specific features commonly found in anaplastic meningioma were hyperchromatic and pleomorphic nuclei and cytoplasmic filaments more obscure than those of the benign counterpart. Immunocytochemically the tumor cells in the papillary area of papillary meningioma had a positive reaction to antiserum of vimentin, cytokeratin and S-100 protein. The tumor cells of anaplastic plastic angiomatous meningioma showed intracytoplasmic positivity to antivimentin and anti-epithelial membrane antigen serum.
细胞诊断是手术中脑肿瘤冰冻切片诊断的有用辅助手段，已在许多病理实验室中应用。虽然间变性（恶性）脑膜瘤并非极为罕见的肿瘤，但其细胞学特征尚未得到充分描述。本文介绍了间变性脑膜瘤、具有纤维母细胞成分的乳头状脑膜瘤和间变性血管性脑膜瘤的细胞学细节。乳头状脑膜瘤显示出与成熟内皮细胞密切相关且对应于乳头状增生的非典型细胞簇。该肿瘤的其他细胞簇显示出具有粗大细胞质丝和细胞质坏死变化的普通纤维母细胞模式。间变性血管性脑膜瘤表现为松散的细胞簇。其中一些有粗大的细胞质丝，另一些在起源上类似于上皮细胞。间变性脑膜瘤常见的特异性特征是核深染和多形性以及比良性对应物更不明显的细胞质丝。免疫细胞化学显示，乳头状脑膜瘤乳头区域的肿瘤细胞对波形蛋白、细胞角蛋白和S-100蛋白抗血清呈阳性反应。间变性血管性脑膜瘤的肿瘤细胞对抗波形蛋白和抗上皮膜抗原血清呈细胞质内阳性。
