克菌丹对哺乳动物细胞的细胞毒性。
Cytotoxicity of captafol in mammalian cells.
作者信息
Rodrigues M A, D'Angelo M
机构信息
Instituto Biológico, São Paulo, Brazil.
出版信息
Biomed Environ Sci. 1994 Sep;7(3):278-83.
PMID:7531451
Abstract
The cytotoxicity of captafol, a phthalimide-derived fungicide, was evaluated in IB-RS-2 cells. Captafol at 0.12-1.0 microgram/ml blocks the cell multiplication. This effect is concentration-dependent, only partially reversible and the degree of inhibition increases with time. The synthesis of DNA and RNA is inhibited in parallel by increasing concentrations of the chemical.
摘要
在IB-RS-2细胞中评估了酞酰亚胺类杀菌剂克菌丹的细胞毒性。0.12-1.0微克/毫升的克菌丹可阻断细胞增殖。这种作用具有浓度依赖性，仅部分可逆，且抑制程度随时间增加。随着该化学物质浓度的增加，DNA和RNA的合成同时受到抑制。
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