Edmunds L H
Ann Thorac Surg. 1978 Dec;26(6):586-9. doi: 10.1016/s0003-4975(10)62947-5.
Indomethacin constricts the patent ductus arteriosus in approximately 70% of premature infants, but temporarily inhibits synthesis of all prostaglandins. Early toxicity of indomethacin is not prohibitive, but the possibility of late neurological deficits is raised by results of laboratory experiments. As yet, no late toxic effects of indomethacin have been observed. However, this possibility and the low morbidity (less than 2%) and mortality (less than 2%) of surgical ligation of the patent ductus arteriosus in premature infants favor operation except in carefully controlled and limited clinical trials.
吲哚美辛可使约70%的早产儿动脉导管闭合，但会暂时抑制所有前列腺素的合成。吲哚美辛的早期毒性并不严重，但实验室实验结果提示存在后期神经功能缺损的可能性。目前，尚未观察到吲哚美辛的后期毒性作用。然而，鉴于这种可能性，以及早产儿动脉导管未闭手术结扎的低发病率（低于2%）和死亡率（低于2%），除了在严格控制和有限的临床试验中，手术治疗更受青睐。
