Backonja M M
Department of Neurology, University of Wisconsin Medical School, Madison.
J Pain Symptom Manage. 1994 Nov;9(8):491-9. doi: 10.1016/0885-3924(94)90110-4.
Local anesthetics administered to block nerve conduction for surgical anesthesia and to provide analgesia in management of acute pain have become a standard of anesthesiology practice. These drugs have had an important role in the multimodality management of chronic pain as well, and this role is expanding since the revival of systemic administration. Local anesthetics are analgesics, albeit not in the traditional clinical and pharmacologic sense. Evidence suggests that intravenous administration is an effective treatment in chronic neuropathic pain syndromes. There is also evidence that intravenous local anesthetics can relieve acute pain. Furthermore, the novel idea that acute procedural and postprocedural pain control with local anesthetics could prevent the development of chronic pain syndromes, including chronic neuropathic pain syndromes, adds another important potential dimension to the role of local anesthetics in pain management.
用于阻断神经传导以进行手术麻醉并在急性疼痛管理中提供镇痛的局部麻醉药已成为麻醉学实践的标准。这些药物在慢性疼痛的多模式管理中也发挥了重要作用，并且自全身给药复兴以来，这一作用正在扩大。局部麻醉药是镇痛药，尽管不是传统临床和药理学意义上的镇痛药。有证据表明静脉内给药是慢性神经性疼痛综合征的有效治疗方法。也有证据表明静脉内局部麻醉药可以缓解急性疼痛。此外，局部麻醉药用于急性操作和操作后疼痛控制可预防慢性疼痛综合征（包括慢性神经性疼痛综合征）发展的新观点，为局部麻醉药在疼痛管理中的作用增添了另一个重要的潜在层面。
