Youinou P, Le Goff P
Laboratoire d'Immunologie, CHU, Brest.
Rev Rhum Ed Fr. 1994 Dec 15;61(10 Pt 2):185S-193S.
Rheumatoid factors are autoantibodies against the Fc fragment of IgGs. The polyclonal rheumatoid factors found in autoimmune diseases are distinct from the monoclonal rheumatoid factors produced in lymphoproliferative disorders in that they rarely express public idiotypes, are relatively specific for their Fc, and exhibit increased affinity. They may be derived from natural rheumatoid factors. The role of the latter is unclear but may involve presentation of immune complex antigens to T cells.
类风湿因子是针对免疫球蛋白G（IgG）Fc片段的自身抗体。自身免疫性疾病中发现的多克隆类风湿因子不同于淋巴增殖性疾病中产生的单克隆类风湿因子，因为它们很少表达公共独特型，对其Fc相对特异，并且亲和力增加。它们可能源自天然类风湿因子。后者的作用尚不清楚，但可能涉及将免疫复合物抗原呈递给T细胞。
