Lees G J, Leong W
Department of Psychiatry and Behavioural Science, School of Medicine, University of Auckland, New Zealand.
Neuroreport. 1994 Oct 27;5(16):2153-6. doi: 10.1097/00001756-199410270-00041.
The non-N-methyl-D-aspartate (NMDA) glutamate agonists are potent convulsants, and cause neuronal loss in many regions of the limbic system in the brain. Kainate or L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and the non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX) were concomitantly injected unilaterally into the rat dorsal hippocampus. Kainate with low doses of NBQX (12.5-25 nmol) almost completely prevented damage to the contralateral but not ipsilateral limbic areas (distal toxicity). In most animals, damage was still found in the contralateral midline thalamic nuclei. In contrast, high doses of NBQX (95-190 nmol) gave no protection to either side. AMPA showed a trend for a reduction in limbic damage to both sides with increasing dose of NBQX. At the highest doses, NBQX prevented damage to both sides.
非N-甲基-D-天冬氨酸（NMDA）谷氨酸激动剂是强效惊厥剂，可导致大脑边缘系统许多区域的神经元丧失。将红藻氨酸或L-α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）与非NMDA拮抗剂2,3-二羟基-6-硝基-7-氨磺酰基苯并（F）喹喔啉（NBQX）单侧注射到大鼠背侧海马体中。低剂量NBQX（12.5 - 25 nmol）与红藻氨酸同时使用时，几乎完全防止了对侧而非同侧边缘区域的损伤（远端毒性）。在大多数动物中，对侧中线丘脑核仍发现有损伤。相比之下，高剂量NBQX（95 - 190 nmol）对两侧均无保护作用。随着NBQX剂量增加，AMPA显示出对两侧边缘损伤减轻的趋势。在最高剂量时，NBQX防止了两侧的损伤。
