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[当前人类甲型和乙型流感病毒群体的多态性]

[Polymorphism of current human influenza A and B virus population].

作者信息

Grinbaum E B, Litvinova O M, Bannikov A I, Konovalenko I B, Chernookaia N Iu, Iukhnova L G, Kiselev O I

出版信息

Vestn Ross Akad Med Nauk. 1994(9):36-40.

PMID:7532493
Abstract

During the past years, the etiological situation has been significantly complicated. It is characterized by simultaneous circulation of A(H1N1), A(H3N2) and influenza B viruses and by the isolation of reassortant strains and viruses, which are atypical in relation to the process of their natural variability. The antigenic properties of epidemic strains and unusual isolates were investigated. The marked heterogeneity of the A(H3N2) influenza viruses was demonstrated. It was determined by the circulation of several antigenic variants during the epidemic. Two separate antigenic lineage of the influenza B viruses--b/Victoria/2/87 and B/Yamagata/16/88--cocirculated in our country in 1991. Since 1986, all the influenza A(H1N1) viruses have been considered to be varieties of the reference strain A/Taiwan/1/86. A direct correlation was found between some atypical viruses and the vaccine strains previously used.

摘要

在过去几年中,病因情况已显著复杂化。其特征是A(H1N1)、A(H3N2)和乙型流感病毒同时传播,以及分离出重配株和病毒,这些重配株和病毒在其自然变异过程中是非典型的。对流行株和异常分离株的抗原特性进行了研究。结果表明A(H3N2)流感病毒具有明显的异质性。这是由几种抗原变异株在流行期间的传播所决定的。1991年,乙型流感病毒的两个独立抗原谱系——b/维多利亚/2/87和B/山形/16/88——在我国共同传播。自1986年以来,所有甲型流感A(H1N1)病毒都被认为是参考株A/台湾/1/86的变种。发现一些非典型病毒与先前使用的疫苗株之间存在直接相关性。

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