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表达沙眼衣原体主要外膜蛋白可变结构域I和IV中和表位的脊髓灰质炎病毒杂种引发广泛交叉反应的沙眼衣原体中和抗体。

Poliovirus hybrids expressing neutralization epitopes from variable domains I and IV of the major outer membrane protein of Chlamydia trachomatis elicit broadly cross-reactive C. trachomatis-neutralizing antibodies.

作者信息

Murdin A D, Su H, Klein M H, Caldwell H D

机构信息

Connaught Centre for Biotechnology Research, Willowdale, Ontario, Canada.

出版信息

Infect Immun. 1995 Mar;63(3):1116-21. doi: 10.1128/iai.63.3.1116-1121.1995.

DOI:10.1128/iai.63.3.1116-1121.1995
PMID:7532625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173119/
Abstract

Trachoma and sexually transmitted diseases caused by Chlamydia trachomatis are major health problems worldwide. Epitopes from the variable domains of the major outer membrane protein are candidates for vaccine development. We have constructed hybrid polioviruses expressing sequences from major outer membrane protein variable domains I and IV. Antisera to the hybrids could, in combination, strongly neutralize 8 of the 12 C. trachomatis serovars most commonly associated with oculogenital infections and weakly neutralize the others.

摘要

沙眼和由沙眼衣原体引起的性传播疾病是全球主要的健康问题。主要外膜蛋白可变区的表位是疫苗开发的候选对象。我们构建了表达主要外膜蛋白可变区I和IV序列的杂交脊髓灰质炎病毒。针对这些杂交病毒的抗血清联合起来能够强力中和12种最常与眼生殖系统感染相关的沙眼衣原体血清型中的8种，并能微弱中和其他血清型。

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Poliovirus hybrids expressing neutralization epitopes from variable domains I and IV of the major outer membrane protein of Chlamydia trachomatis elicit broadly cross-reactive C. trachomatis-neutralizing antibodies.表达沙眼衣原体主要外膜蛋白可变结构域I和IV中和表位的脊髓灰质炎病毒杂种引发广泛交叉反应的沙眼衣原体中和抗体。
Infect Immun. 1995 Mar;63(3):1116-21. doi: 10.1128/iai.63.3.1116-1121.1995.
2
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本文引用的文献

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Attenuated poliovirus strain as a live vector: expression of regions of rotavirus outer capsid protein VP7 by using recombinant Sabin 3 viruses.减毒脊髓灰质炎病毒株作为活载体：利用重组萨宾3型病毒表达轮状病毒外衣壳蛋白VP7的区域
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