Sigmundson H K
Mental Health Services, Ministry of Health, Province of British Columbia.
Can J Psychiatry. 1994 Nov;39(9 Suppl 2):S70-5.
Traditional antipsychotic medications have targeted the dopamine system. Yet, the isolation and cloning of multiple dopamine receptor subtypes and the recognition of non-dopaminergic pathways (for example, serotonin) in schizophrenia have led to the development of new pharmacological strategies in pharmacotherapy. The author summarizes recent biochemical and pharmacological data and the clinical experience with novel antischizophrenic compounds.
传统抗精神病药物作用于多巴胺系统。然而，多种多巴胺受体亚型的分离与克隆以及对精神分裂症中非多巴胺能通路（如5-羟色胺）的认识，促使了药物治疗新策略的发展。作者总结了近期关于新型抗精神分裂症化合物的生化和药理学数据以及临床经验。
