Morikawa T, Kobayashi S, Yamadori I, Okino T, Hirakawa E, Kurose A, Ohmori M, Kobayashi M
Department of Pathology, Kagawa Medical School, Japan.
Indian J Cancer. 1994 Dec;31(4):268-73.
Small cell carcinomas are fairly common neoplasms in the lung, but tumors featuring similar histological profiles may occur in extrapulmonary organs. Three cases of small cell carcinomas occurring in the prostate (case 1), stomach (case 2), and pancreas (case 3) are presented. Production of hormones was demonstrated immunohistochemically in all cases. In case 2 alpha-fetoprotein (AFP) was elevated in the serum and observed immunohistochemically in tumor cells. Production of AFP is a distinctive feature, which has not been reported in the pulmonary and extrapulmonary cases of small cell carcinoma. Amplification and/or expression of myc gene family have been suggested to be related to the prognosis of pulmonary small cell carcinoma. Amplification of myc genes was not detected in any of our cases, but c-myc protein was demonstrated immunohistochemically in tumor cells of case 1.
小细胞癌是肺部较为常见的肿瘤，但具有相似组织学特征的肿瘤也可能发生于肺外器官。本文报告了3例分别发生于前列腺（病例1）、胃（病例2）和胰腺（病例3）的小细胞癌。所有病例均通过免疫组化证实有激素产生。病例2血清中甲胎蛋白（AFP）升高，并在肿瘤细胞中通过免疫组化观察到。AFP的产生是一个独特的特征，在肺和肺外小细胞癌病例中尚未见报道。有人提出myc基因家族的扩增和/或表达与肺小细胞癌的预后有关。在我们的任何病例中均未检测到myc基因的扩增，但在病例1的肿瘤细胞中通过免疫组化证实有c-myc蛋白表达。
