[P物质对新鲜分离的大鼠背根神经节神经元中γ-氨基丁酸激活电流的抑制作用]
[Inhibitory effect of SP on GABA-activated currents in freshly isolated rat DRG neurons].
作者信息
Wu X P, Li Z W, Fan Y Z
机构信息
Research Center of Experimental Medicine, Tongji Medical University, Wuhan.
出版信息
Sheng Li Xue Bao. 1994 Dec;46(6):586-90.
The whole-cell patch-clamp technique was used to record GABA-activated currents in freshly isolated DRG neurons. It was found that application of SP (10(-7)-10(-5) mol/L) could induce concentration dependent inward currents in some cells (4/26), while no such current was detectable in the other neurons. However, preapplication of SP could inhibit the inward currents mediated by GABAA receptor (18/22). The inhibitory effect of SP was concentration dependent and reversible, and the desensitization of GABA-activated current could also be enhanced by SP.
采用全细胞膜片钳技术记录新鲜分离的背根神经节（DRG）神经元中γ-氨基丁酸（GABA）激活的电流。发现应用P物质（SP，10⁻⁷ - 10⁻⁵ mol/L）可在一些细胞（4/26）中诱导出浓度依赖性内向电流，而在其他神经元中未检测到这种电流。然而，预先应用SP可抑制由GABAA受体介导的内向电流（18/22）。SP的抑制作用具有浓度依赖性且可逆，并且SP还可增强GABA激活电流的脱敏作用。
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