Stevens R B, Ansite J D, Lokeh A, Rossini T J, Mills C D, Sutherland D E
Department of Surgery, University of Minnesota, Minneapolis.
Transplant Proc. 1995 Feb;27(1):615-6.
Intrahepatic NO production is related to the islet mass transplanted. Nitric oxide production is higher in recipients of allogeneic rather than syngeneic islets. In addition, in allogeneic recipients a possible second peak of NO production was observed at 120 hours corresponding to the time of cellular rejection of the islet grafts (P = .22 vs 96 hours). Finally, the time to rejection of Wistar rat donor islets transplanted into Lewis rat diabetic recipients treated with NMA was not affected. However, inhibiting NO production in the minimal islet transplant model decreased the time to islet function, it does not affect the time to clinical rejection in recipients of a high number of allogeneic islet, which functions immediately. High-level NO has been shown to inhibit T-cell activation in vitro, and thus decreasing the levels by administrating NMA may accentuate the rejection response, canceling out the beneficial effect that might otherwise have occurred on islet function. Further experiments are required to clarify these issues.
肝内一氧化氮（NO）的产生与移植的胰岛质量有关。同种异体胰岛受体中一氧化氮的产生高于同基因胰岛受体。此外，在同种异体受体中，在120小时观察到一个可能的NO产生的第二个峰值，这与胰岛移植的细胞排斥时间相对应（与96小时相比，P = 0.22）。最后，移植到用NMA治疗的Lewis大鼠糖尿病受体中的Wistar大鼠供体胰岛的排斥时间不受影响。然而，在最小胰岛移植模型中抑制NO的产生缩短了胰岛发挥功能的时间，但不影响大量同种异体胰岛立即发挥功能的受体的临床排斥时间。高水平的NO已被证明在体外可抑制T细胞活化，因此通过给予NMA降低NO水平可能会加剧排斥反应，抵消原本可能对胰岛功能产生的有益作用。需要进一步的实验来阐明这些问题。
